Protective mechanisms of atorvastatin in ameliorating doxorubicin‐induced hepato‐renal toxicity
نویسندگان
چکیده
منابع مشابه
Protective Effect of Atorvastatin on Benzopyrene-Induced Hepatorenal Toxicity: A Histopathological Study
Background and purpose: Benzo[a]pyrene (BaP) is an environmental pollutant that has genotoxic and carcinogenic effects. Atorvastatin (ATV), as a lipid-lowering drug, has antioxidant, anti-inflammatory and anti-apoptotic properties. This study investigated the effects of ATV on chronic liver and kidney damage induced by BaP. Materials and methods: In this experimental study, adult female rats w...
متن کاملProtective Role of Adansonia digitata Extract Against Glyphosate-induced Hepatorenal Toxicity in Adult Male Wistar Rats
Background: Glyphosate is the most widely used herbicide, and it poses numerous health risks to the environment and living organisms. This study aimed at assessing the protective role of Adansonia digitata (A. digitata) on glyphosate-induced hepatorenal toxicity in a Wistar rat model. Methods: Twenty-five rats were randomly divided into five groups of five animals each. The first group did not...
متن کاملProtective effect of Rheum turkestanicum root against mercuric chloride-induced hepatorenal toxicity in rats
Objective: The present study was designed to investigate the protective effects of hydroalcoholic extract of Rheum turkestanicum against HgCl2 hepatorenal toxicity in rats. Materials and Methods: Animals were randomly divided into five groups (n= 6 in each group) and received HgCl2 and plant’s extract, intraperitoneally. Group1 received saline (1 mL/kg/day), group 2 received extract (200 mg/kg/...
متن کاملHepatorenal Protective Effects of Sesame Seeds Oil, Flaxseed Oil and their Mixture against Methotrexate Toxicity in Rats
Background: Methotrexate (MTX) is an anti-metabolite drug used in the treatment of many cancers and autoimmune diseases. Methods: This study investigated the protective effect of flaxseed oil, sesame seed oil, and their mixture on the MTX-induced hepatorenal toxicity. Thirty rats divided into five groups of: normal control, MTX control, and flaxseed oil, sesame seed oil, and the mixture groups...
متن کاملThe Protective Role of Colchicine on Diclofenac Sodium Induced Hepatorenal Toxicity in Albino Rats Model
Diclofenac (DIC) is a widely used as an antiinflammatory drug and it is used as the toxicant in hepatoprotective studies. In the present study, hepato-renal protective activity of Colchicine against DIC induced liver and kidney injury in albino rats was assessed. Animals were injected with Diclofenac sodium at the single dose of 150 mg/ kg body weight daily for 28 days. Oral administration of c...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2013
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.27.1_supplement.lb638